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[125I]AT-1012, a new high affinity radioligand for the α3β4 nicotinic acetylcholine receptors

✍ Scribed by Wu, Jinhua; Perry, David C.; Bupp, James E.; Jiang, Faming; Polgar, Willma E.; Toll, Lawrence; Zaveri, Nurulain T.


Book ID
122388571
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
722 KB
Volume
77
Category
Article
ISSN
0028-3908

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We have prepared (S)-5-chloro-3-[ 1251]iodo-2-methoxy-N-( l-azabicyclo[2.2.2]oct-3-yl)benzamide ([125I]DAIZAC, [ 1254-3) as a radioligand for characterization of the 5-HT-3 receptor. Preparation of the 3-tri-n-butylstannyl precursor was accomplished from the corresponding unlabeled DAIZAC by reactio