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1,25-dihydroxyvitamin D3 impairs NF-κB activation in human naïve B cells

✍ Scribed by Kerstin Geldmeyer-Hilt; Guido Heine; Björn Hartmann; Ria Baumgrass; Andreas Radbruch; Margitta Worm

Book ID: 116301596
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 390 KB
Volume: 407
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2011.03.078

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## Abstract Treatment with 10^−8^ m 1,25‐dihydroxyvitamin D~3~ for 24 h causes transcriptional activation of the human insulin receptor gene in U‐937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinosito