1,25-DIHYDROXYVITAMIN D3 AND BREAST CANCER
β Scribed by J. A. Eisman; L. J. Suva; R. J. Frampton
- Book ID
- 119842350
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 303 KB
- Volume
- 54
- Category
- Article
- ISSN
- 1445-1433
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## Abstract Aberrant constitutive expression of the NFβΞΊB cβRel and RelA subunits in breast cancer cells was shown to promote their survival. Recently, we demonstrated that aggressive breast cancers constitutively express high levels of the RelB subunit, which promotes their more invasive phenotype
The replication of several human and animal cancer cell lines is regulated in vitro and in vivo by 1,25-dihydroxyvitamin D3 I 1 ,25-(OH),D3], the hormonally active form of vitamin Uj. We have examined the effects of concentrations of 1 ,25-(OH)2D3, which inhibit cellular replication, on the cell-cyc