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1,2,4-Triazine N-Oxide Derivatives: Studies as Potential Hypoxic Cytotoxins. Part 2.

✍ Scribed by Hugo Cerecetto; Mercedes Gonzalez; Silvia Onetto; Patricia Saenz; Olga Ezpeleta; Adela Lopez de Cerain; Antonio Monge


Publisher
John Wiley and Sons
Year
2004
Weight
108 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Several new 1,2,5-oxadiazole N-oxide derivatives were synthesized to be tested both as potential selective hypoxic cell cytotoxins and as DNA-binding agents. The compounds prepared included bis(1,2,5-oxadiazole N-oxide) derivatives and oxadiazole rings linked to naphthyl residues. The compounds were