## Abstract Initial investigations towards the synthesis and glutamate receptor activity of triazolyl amino acids are undertaken.
1,2,3-Triazolyl amino acids as AMPA receptor ligands
✍ Scribed by N.J. Stanley; D. Sejer Pedersen; B. Nielsen; T. Kvist; J.M. Mathiesen; H. Bräuner-Osborne; D.K. Taylor; A.D. Abell
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 477 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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We have previously shown that whereas (RS)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid (APPA) shows the characteristics of a partial agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, (S)-APPA is a full AMPA receptor agonist and (R)-APPA a weak
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