𝔖 Bobbio Scriptorium
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1207 Intracerebral grafting of genetically modified cells to produce basic fibroblast growth factor

✍ Scribed by Takayama, Hideichi; Toya, Shigeo; Gage, Fred H.


Book ID
123148316
Publisher
Elsevier Science
Year
1993
Weight
94 KB
Volume
18
Category
Article
ISSN
0921-8696

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Basic fibroblast growth factor (bFGF) is found in a variety of cells and tissues. We have previously shown that bFGF is a transforming growth factor, but only when fused to a signal peptide (sp-bFGF). Cells expressing the native bFGF are tumorigenic in nude mice only, where the tumors form at a low