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12-O-tetradecanoylphorbol-13-acetate (TPA) induces sister-chromatid exchanges and delays in cell progression in Chinese hamster ovary and human cell lines

โœ Scribed by Jeffrey L. Schwarts; Michael J. Banda; Sheldon Wolff


Book ID
113192353
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
869 KB
Volume
92
Category
Article
ISSN
0027-5107

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Culture of cells in high exogenous levels (greater than 10(-4) M) of bromodeoxyuridine (BrdUrd) or thymidine will increase the baseline sister chromatid exchange (SCE) frequency. The effect is thought to be related to the balance of the DNA precursors thymidine and deoxycytidine. Exogenous addition