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1,2-dithia-5-azacyclooctan-6-one and related compounds: Synthesis and conformation

✍ Scribed by Susana Caveda Cepas; Michael North


Book ID
108378804
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
427 KB
Volume
53
Category
Article
ISSN
0040-4020

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ChemInform Abstract: 1,2-Dithia-5-azacyc
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## Synthesis and Conformation. -The first synthesis of the parent 1,2-dithia-5azacyclooctan-6-one (IV) and the substituted derivatives (VII) is described. Compounds (IV) and (VIIa) exist in solution in a conformation with a transamide bond, (VIIb) shows three conformations with the major conformer

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## Abstract The synthetic routes of 6,7‐dihydrobenzo[4,5]cyclohept[1,2‐__b__]indol‐12(5__H__)‐one 5 from either 1‐methyl or 1‐sulfonylindole‐2‐carboxaldehyde 1 or ethyl 1,2‐dimethylindole‐3‐carboxylate 6 are reported. The structure of the ketone 5a was confirmed by X‐ray crystallography. Several in