1,2-Dioxines as Masked cis γ-Hydroxy Enones and Their Versatility in the Synthesis of Highly Substituted γ-Lactones.

ChemInform Abstract: ATP-Citrate Lyase a

ChemInform Abstract: ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R*,5S*)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo.

✍ A. D. GRIBBLE; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 2 views

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R\*,5S\*)-ω-Substituted-3carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo. -A series of the title compounds is synthesized and evalua