✦ LIBER ✦

1,2-dihydro-3,1-benzoxazin-4-one and 4H-1,2-dihydro-pyrido-[2,3-d]-[1,3]-oxazin-4-one derivatives as potential prodrugs: Part III: Permeability through excised human skin in vitro

✍ Scribed by Gerhard Schwenker; Jianbing Chen

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 283 KB
Volume: 324
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.2503241113

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✦ Synopsis

The percutaneous permeation characteristics of 6 potential prodrugs 2-7 in comparison with their parent drug mefenamic acid (1) in virro using excised human skin were studied. The results show that all potential prodrugs tested were at least 2.0 times as effective as mefenamic acid; compounds 2 and 7 as ,,,,=fedc =id through excised human skin, between the behaviour, the R~ values and the melting points were interpreted. 1 J -D i h y d ~~l -b e n z o M ~n ~n -und 4H-lJ-Dihydrcbpyrldcb[2-

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