From a library of 23 N-substituted title compounds, e.g. (I) and (II), derivative (Id) emerges as most potent and selective tryptase inhibitor besides derivatives (Ib) and (Ic). -(COMBRINK, KEITH D.; GUELGEZE,
1,2-Benzisothiazol-3-one 1,1-Dioxide Inhibitors of Human Mast Cell Tryptase
✍ Scribed by Combrink, Keith D.; Gülgeze, H. Belgin; Meanwell, Nicholas A.; Pearce, Bradley C.; Zulan, Pi; Bisacchi, Gregory S.; Roberts, Daniel G. M.; Stanley, Paul; Seiler, Steven M.
- Book ID
- 126910263
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 143 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
In the title molecule, C 14 H 11 NO 3 S, the benzoisothiazole ring system and the benzyl group form a dihedral angle of 87.7 (9) . The crystal structure is stabilized by weak intermolecular C-HÁ Á ÁO hydrogen bonds.
In the title molecule, C 15 H 9 Cl 2 NO 4 S, all bond lengths and angles are within normal ranges. In the crystal structure, the molecules are linked into a three-dimensional network via weak C-HÁ Á ÁO hydrogen bonds.