𝔖 Bobbio Scriptorium
✦   LIBER   ✦

111In-Oxine-labelled autologous leucocytes in inflammatory bowel disease: New scintigraphic activity index

✍ Scribed by A. Ybern; J. Martin-Comin; J. J. Giné; T. Casanovas; R. Villa; M. A. Gassull

Book ID
104683855
Publisher
Springer
Year
1986
Tongue
English
Weight
569 KB
Volume
11
Category
Article
ISSN
0340-6997

No coin nor oath required. For personal study only.

✦ Synopsis

The usefulness of scintigraphy with 111In-oxine-labelled autologous leucocytes was investigated in 27 patients with inflammatory bowel disease (IBD): 16 with ulcerative colitis and 11 with Crohn's disease. Scans were performed 2-4 h (early scan) and at 24 h (late scan) after leucocyte reinjection. No false-negative results occurred in the early scan; however, in the late scan, 2 patients with Crohn's disease had a normal scintigram. A new index of activity (Il) based on the number and relative activity of abnormal 111In-leucocyte zones was used for scan quantitation. All patients with clinically active IBD had Il greater than or equal to 2. The scintigraphic index showed a significant correlation with the Harvey clinical index, especially in patients with ulcerative colitis. Our results suggest that an early scan (2-4 h) provides useful information in cases of IBD, and that Il greater than or equal to 2 is indicative of the degree of disease activity in such patients.

📜 SIMILAR VOLUMES

Granulocyte-specific monoclonal antibody
Granulocyte-specific monoclonal antibody technetium-99m-BW 250/183 and indium-111 oxine-labelled leucocyte scintigraphy in inflammatory bowel disease
✍ I. Segarra; M. Roca; C. Baliellas; L. Vilar; Y. Ricart; J. Moral; R. Puchal; J. 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 805 KB

Thirty-three patients suspected of suffering from inflammatory bowel disease were studied. Autologous leucocytes were labelled with indium 111 oxine and re-injected simultaneously with 0.3-0.5 mg of technetium 99m granulocyte-specific monoclonal antibody BW 250/ 183. Two scans were obtained, the ear

Technetium-99m hexamethyl propylene amin
Technetium-99m hexamethyl propylene amine oxine leucocytes in the assessment of disease activity in inflammatory bowel disease
✍ Eila Lantto; Kari Järvi; Iikka Krekelä; Tuomo Lantto; Matti Taavitsainen; Heikki 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 655 KB

The inflammatory activity in 108 bowel segments of 40 patients with suspected or known inflammatory bowel disease was assessed macroscopically by endoscopy, histology and technetium-99m hexamethyl propylene amine oxine (99mTc-HMPAO) leucocytes using a numerical grading system (scores 0-3). A 4-h ser

Obestatin/ghrelin ratio: A new activity
Obestatin/ghrelin ratio: A new activity index in inflammatory bowel diseases
✍ Efstratios Alexandridis; Athanasios Zisimopoulos; Nikolaos Liratzopoulos; Ioanni 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB

## Background: The aim was to determine obestatin and ghrelin serum levels and their ratio in inflammatory bowel disease (IBD) patients. ## Methods: We measured the ghrelin and obestatin levels of 31 Crohn's disease patients and 22 patients with ulcerative colitis using a radioimmunoassay metho