Technetium-99m hexamethyl propylene amine oxine leucocytes in the assessment of disease activity in inflammatory bowel disease

✍ Scribed by Eila Lantto; Kari Järvi; Iikka Krekelä; Tuomo Lantto; Matti Taavitsainen; Heikki Vedenkangas; Martti Vorne

• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 655 KB
• Volume: 19
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00178302

✦ Synopsis

The inflammatory activity in 108 bowel segments of 40 patients with suspected or known inflammatory bowel disease was assessed macroscopically by endoscopy, histology and technetium-99m hexamethyl propylene amine oxine (99mTc-HMPAO) leucocytes using a numerical grading system (scores 0-3). A 4-h series of scintigrams showed a significant correlation with both histological and macroscopical assessment of disease activity (rho=0.850, P<0.00I and rho=0.773, P<0.001, respectively). Sensitivity, specificity and accuracy of scintigraphy in detecting active inflammatory segments were 85%, 92% and 89%, respectively. A normal scintigram did not completely exclude mild inflammatory activity, especially in the rectosigmoid area. 99mTc-HMPAO leucocytes offer an accurate and non-invasive alternative for the assessment of disease activity in ulcerative colitis and Crohn's disease.