## Abstract **BACKGROUND:** Neural tube defects (NTDs) are one of the most common human birth defects, with a prevalence of approximately 1 in 1000 live births in the United States. In animal studies, deletion of __p53__ leads to a significant increase in embryos that exhibit exencephaly. Whereas s
11-P013 Gene expression in WT and Pkd2 mutant mouse embryos
โ Scribed by Petra Pennekamp; Stefan Feldner; Gerrit Randau; Nadia Koo; Peter Wieacker; Bernd Dworniczak
- Book ID
- 119327990
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 46 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0925-4773
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## Abstract Short, hairpin RNA (shRNA) directed against bone morphogenetic protein 4 (Bmpโ4) was delivered to early postimplantation staged mouse embryos via tail vein injection of pregnant dams. As early as 24 h postinjection, embryos expressed a DsRed marker and later exhibited defects of neural