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1091 Proteasome-dependent degradation of the cholangiocyte apical bile acid transporter (ASBT) regulates transport activity in cholangiocytes

โœ Scribed by XIA, X; ROUNDTREE, M; LU, X; SHENTU, S; NAJAM, A; MERIKHI, A; LESAGE, G


Book ID
122001861
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
152 KB
Volume
38
Category
Article
ISSN
0270-9139

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Secretin activation of the apical Na+-de
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The role of the cholangiocyte apical Na ุ‰ -dependent bile acid transporter (ASBT) in bile formation is unknown. Bile acid absorption by bile ducts results in cholehepatic shunting, a pathway that amplifies the canalicular osmotic effects of bile acids. We tested in isolated cholangiocytes if secreti