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Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes

โœ Scribed by G Alpini; SS Glaser; R Rodgers; JL Phinizy; WE Robertson; J Lasater; A Caligiuri; Z Tretjak; GD LeSage


Book ID
119755842
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
593 KB
Volume
113
Category
Article
ISSN
0016-5085

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Secretin activation of the apical Na+-de
โœ Gianfranco Alpini; Shannon Glaser; Leonardo Baiocchi; Heather Francis; Xuefeng X ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 439 KB

The role of the cholangiocyte apical Na ุ‰ -dependent bile acid transporter (ASBT) in bile formation is unknown. Bile acid absorption by bile ducts results in cholehepatic shunting, a pathway that amplifies the canalicular osmotic effects of bile acids. We tested in isolated cholangiocytes if secreti