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107 Somatic MLH1 Promoter Hypermethylation Is a Frequent Event in Lynch Syndrome Colorectal Cancers

✍ Scribed by Moreira, Leticia; Munoz, Jenifer; Cuatrecasas, Miriam; Quintanilla, Isabel; Leoz, Maria Liz; Carballal, Sabela; Ocana, Teresa; Fernandez, Patricia; Arnold, Mildred; Pellise, Maria; Jover, Rodrigo; Andreu, Montserrat; Carracedo, Angel; Llor, Xavier; Boland, C. Richard; Goel, Ajay; Castells, Antoni; Balaguer, Francesc

Book ID: 122121182
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 62 KB
Volume: 144
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(13)60087-6

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## Abstract Cell adhesion molecule 1 (CADM1/TSLC1), a putative tumor suppressor involving in cell adhesion, proliferation and apoptosis, is frequently inactivated in several carcinomas due to promoter hypermethylation. But alterations of CADM1/TSLC1 in colorectal carcinogenesis and clinical signifi