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1067-140 Subnormal tissue inhibitor of metalloproteinase expression modulates matrix metalloproteinase-2 activity and fibrosis in aortic regurgitation

โœ Scribed by Karlheinz Schuleri; Eungsuk Lee; Lisa L Pitlor; Sharada L Truter; Jeffrey S Borer


Book ID
119549432
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
105 KB
Volume
43
Category
Article
ISSN
1558-3597

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## Background: Matrix metalloproteinase-2 (mmp-2), which degrades the extracellular matrix or the basement membrane, has an essential role in tumor invasion and metastasis. to evaluate the roles of mmp-2, its inhibitor (tissue inhibitor of metalloproteinase-2 [timp-2]), and its activator (membrane-