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106 Preclinical studies and characterization of BMS-794833, a small molecule inhibitor of Met and VEGFR-2 kinases

✍ Scribed by J. Fargnoli; B.J. Henley; B.S. Wautlet; R. Borzilleri


Book ID
119602788
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
60 KB
Volume
8
Category
Article
ISSN
1359-6349

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BMS-690514, a potent inhibitor of human epidermal growth factor receptor (HER) 1 (EGFR), 2, and 4, and vascular endothelial growth factor receptors (VEGFR) 1-3, is currently under investigation as an oral agent for the treatment of solid tumors. In vitro and in vivo studies were conducted to charact