## Background: A critical factor for successful organ preservation treatment in head and neck cancer may be selecting tumors that respond to chemotherapy and radiation. previous results in patients indicated that tumors that overexpressed p53 were more sensitive to chemotherapy than those that did
106 Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients
β Scribed by J. Akervall; X. Guo; M. Qian; J. Schoumans; J. Yuhas; T. Carey; B. Leeser; C. Bradford; J. Tennvall; B. Teh
- Book ID
- 118620281
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 179 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1359-6349
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## Abstract ## Background Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance. ##
## Abstract ## Background The purpose of this study was to investigate the potential role of variable microRNA (miRNA) expression in the development of multidrug resistance (MDR) in head and neck cancer. ## Methods Head and neck squamous cell carcinoma cell lines UMSCCβ1 and SQ20B were treated w
## Abstract Resistance to cisplatin is a major obstacle to successful treatment of head and neck squamous cell carcinoma (HNSCC). To investigate the molecular mechanism of this resistance, we compared the gene expression profiles between the cisplatinβsensitive SCC cell lines (Saβ3, Hβ1 and KB) and