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1045 Mutant p53 transfection of astrocytic cells results in altered cell cycle control, radiation sensitivity, and tumorigenicity

✍ Scribed by Kirk E. Kanady; Mei Su; Gary Proulx; David M. Malkin; Francisco S. Pardo

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 106 KB
Volume: 32
Category: Article
ISSN: 0360-3016
DOI: 10.1016/0360-3016(95)97870-7

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## Abstract We investigated the mechanism of radiation induction of murine thymic lymphomas by studying the characteristics of primary x‐ray–induced thymic lymphoma (PXTL) cell lines and of their oncogene‐induced, progressed progeny. It is widely thought that proto‐oncogene alterations are associat