𝔖 Bobbio Scriptorium
✦   LIBER   ✦

10 - Founding BRCA1 mutations in Austrian HBOC families

✍ Scribed by T. Wagner; R. Möslinger; D. Muhr; K. Hirtenlehner; P. Underhill; M. Pec; H. Breiteneder; E. Kubista; P. Defner


Book ID
117664272
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
288 KB
Volume
33
Category
Article
ISSN
0959-8049

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


New mutation in BRCA1 gene detected in A
✍ T.M.U. Wagner; R. Möslinger; O. Scheiner; H. Breiteneder; P. Devilee 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 106 KB

Germline mutations in the BRCAl gene confer susceptibility to hereditary breast and ovarian cancer . We report a new mutation in the BRCAl gene in an Austrian hereditary breast and ovarian cancer (HBOC) family with four breast cancer cases and one ovarian cancer in three generations. The average age

BRCA1-related breast cancer in Austrian
✍ Teresa M. U. Wagner; Regine A. Möslinger; Daniela Muhr; Gudrun Langbauer; Kora H 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 76 KB 👁 2 views

We identified 17 BRCA1 mutations in 86 Austrian breast and ovarian cancer families (20%) that were screened for mutations by denaturing high-performance liquid chromatography (DHPLC) and the protein truncation test (PTT). Eleven distinct mutations were detected, 4 of them (962del4, 2795del4, 3135del

BRCA1 mutations in German breast-cancer
✍ Burkhard Jandrig; Klaus Grade; Susanne Seitz; Beate Waindzoch; Manuela Müller; E 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 488 KB 👁 2 views

We analyzed germline mutations of the BRCAl gene in 20 German breast/ovarian-cancer families. BRCA I mutations cosegregating with breast-cancer susceptibility were identified in 3 of these families. All mutations were found to generate a premature stop codon leading to the synthesis of truncated BRC