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1-Trifluoromethyl Epoxy Ethers. Effect of Hexafluoro-2-propanol on Reactions with Secondary Aromatic Amines: Synthesis of 3-Trifluoromethyl Indole Derivatives

✍ Scribed by Rodrigues, Isabelle; Bonnet-Delpon, Danièle; Bégué, Jean-Pierre


Book ID
121338301
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
107 KB
Volume
66
Category
Article
ISSN
0022-3263

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Reactions of 3-([(trifluoromethyl)sulfon
✍ Béatrice Malapel-Andrieu; Jean-Yves Mérour 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 812 KB

Indolic triflate reacted with 1,2-diamines to afford pyrazino[2,3-b]indole or indolo[2,3-b] quinoxaline. Carbon nucleophiles such as malonate derivatives also reacted with indolic triflate in absence of palladium catalyst to afford 2-(3-oxo-2,3-dihydro-1H-2-indolyliden) malonate derivatives.