1-(tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur) determined in rat hair as an index of drug exposure

High-pressure liquid chromatographic det

High-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur

✍ Teruyoshi Marunaka; Yukihiko Umeno; Kozo Yoshida; Masahiro Nagamachi; Yoshinori 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 591 KB

Oral adminstration of uracil plus ftorafur [ 1-(tetrahydro-2-furanyl)-5-fluorouracil] has a greater antitumor effect than that of ftorafur alone. A high-pressure liquid chromatographic method was developed for the determination of ftorafur in plasma and visceral tissues with a sensitivity of 0.025 l