## Abstract Physical activity has been shown to be neuroprotective in lesions affecting the basal ganglia. Using a treadmill exercise paradigm, we investigated the effect of exercise on neurorestoration. The 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐lesioned mouse model provides a means t
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine–induced lipid peroxidation and DNA damage in mouse bone marrow and blood
✍ Scribed by Genaro G. Ortiz; Guillermo Zúñiga-González; Joaquín J. García; Olivia Torres-Bugarín; Ana Zamora-Perez; Oscar K. Bitzer-Quintero
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 220 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.10133
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The present study examines the motor responses of 10-to 12-month-old, male C57 mice that were either given intraperitoneal (IP) injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg per day) or vehicle for 10 consecutive days, followed by IP injections of levodopa (200 mg/kg) pl
## Abstract ## Objective The objective of the present study was to investigate the effect of docosahexaenoic acid (DHA), a polyunsaturated fatty acid (omega‐3), on levodopa‐induced dyskinesias (LIDs) in parkinsonian 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)–treated monkeys. ## Methods
Previous studies have suggested a role for the retrograde messenger, nitric oxide (NO), in methamphetamine (METH)-and 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Since evidence supported the involvement of the neuronal nitric oxide synthase (nNOS) isoform i
## Abstract Administration of the neurotoxicant 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) to C57BL/6 mice targets nigrostriatal dopaminergic neurons, leading to cell death and the depletion of striatal dopamine. After MPTP lesioning in young adult mice, surviving nigrostriatal dopaminergi