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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) enhances tryptophan hydroxylase activity in mouse striatum, but not in the frontal cortex

✍ Scribed by Hidetoshi Fukuda; Kenji Hara; Shigenobu Nakamura; Hiroshi Kimura; Masakuni Kameyama


Book ID
115798657
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
278 KB
Volume
449
Category
Article
ISSN
0006-8993

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP