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1-Methyl- 1,2,3,4-Tetrahydroisoquinoline, Decreasing in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mouse, Prevents Parkinsonism-Like Behavior Abnormalities

✍ Scribed by Yoshikazu Tasaki; Yukiko Makino; Shigeru Ohta; Masaaki Hirobe


Book ID
111176205
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
430 KB
Volume
57
Category
Article
ISSN
0022-3042

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP