## Abstract The condensation reaction of glycine and alanine hydroxamic acids with piperidone (II) regioselectively affords the title spiro compounds (III), which are capable of enhancing sensitivity of P388 and L1210 leukemias in mice models to the known anticancer drugs cisplatin and cyclophospha
✦ LIBER ✦
1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy
✍ Scribed by Igor V. Vystorop; Nina P. Konovalova; Tat’yana E. Sashenkova; Elena N. Berseneva; Alexander V. Chernyak; Boris S. Fedorov; Remir G. Kostyanovsky
- Book ID
- 113798679
- Publisher
- Royal Society of Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 370 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0959-9436
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
ChemInform Abstract: 1-Hydroxy-8-methyl-
✍
Igor V. Vystorop; Nina P. Konovalova; Tat'yana E. Sashenkova; Elena N. Berseneva
📂
Article
📅
2012
🏛
John Wiley and Sons
⚖ 31 KB
👁 1 views
In vivo evaluation of [123I]-8-[4-[2-(5-
✍
Rikki N. Waterhouse; J.Timothy Gotsick; George W. Kabalka; Mark M. Goodman; J.C.
📂
Article
📅
1998
🏛
Elsevier Science
🌐
English
⚖ 391 KB
SYNTHESIS OF 3-METHYLENE-1-OXA-8-HETERAS
✍
Satyamurthy, Nagichettiar; Berlin, K. Darrell; Powell, Douglas R.; Helm, Dick Va
📂
Article
📅
1984
🏛
Informa UK (Taylor & Francis)
⚖ 1017 KB
Isolation and Synthesis of N-(2-Methyl-3
✍
Ángel Cantín; Pilar Moya; Maria-Angeles Castillo; Jaime Primo; Miguel A. Miranda
📂
Article
📅
1999
🏛
John Wiley and Sons
🌐
English
⚖ 132 KB
👁 2 views
Two new natural products, N- (2-methyl-3-oxodec-8-enoyl)corresponding acid chloride, in order to acylate Meldrum's acid. Subsequent aminolysis with pyrrolidine, followed by 2-pyrroline (2) and 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8atetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (3), have been methylation
A new procedure for regioselective synth
✍
Gary L. Grunewald; Vidyadhar M. Paradkar; Duane M. Stillions; Feei Ching
📂
Article
📅
1991
🏛
Journal of Heterocyclic Chemistry
🌐
English
⚖ 449 KB
Synthesis and in vivo evaluation of [O-m
✍
J.S. Dileep Kumar; Jaya Prabhakaran; Kjell Erlandsson; Vattoly J. Majo; Norman R
📂
Article
📅
2006
🏛
Elsevier Science
🌐
English
⚖ 376 KB