1 H N.M.R. Studies of Protonation in Pyridazin-3 (2H)-one and 6-Hydroxypyridazin-3 (2H)-one
✍ Scribed by Barlin, GB; Fenn, MD
- Book ID
- 118126397
- Publisher
- Commonwealth Scientific and Industrial Research Organisation Publishing
- Year
- 1979
- Tongue
- English
- Weight
- 304 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0004-9425
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📜 SIMILAR VOLUMES
This study of the title compound, C 14 H 9 F 3 N 4 O, is part of a series of structural investigations of cyclooxygenase-2 (COX-2) inhibitors containing 1,3-diarylpyrazole derivatives. The crystal structure is stabilized by intermolecular N-HÁ Á ÁO and C-HÁ Á ÁF hydrogen-bonding interactions.
## Abstract The new 1H‐pyrazole‐3‐carboxylic acid **2**, pyridazin‐3(2H)‐one **3**, and their various derivatives were prepared by the reactions of the 4‐benzoyl‐5‐phenyl‐2,3‐dihydro‐2,3‐furandione **1** and 2,5‐dichlorophenylhydrazine. Pyrazolo[3,4‐d]pyridazine **7** was obtained from cyclization