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1-Benzoyl-2(S)-tert-butyl-4-methoxy-6(S)-carbo­methoxy-1,2,5,6-tetra­hydro-1,3-pyrimidine: a useful precursor of α-alkyl­ated aspartic acids

✍ Scribed by Giraldés, José ;McLaughlin, Mark L. ;Fronczek, Frank R.

Publisher
International Union of Crystallography
Year
2002
Tongue
English
Weight
183 KB
Volume
58
Category
Article
ISSN
1600-5368

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✦ Synopsis

Single-crystal X-ray study T = 120 K Mean '(C±C) = 0.003 A Ê R factor = 0.039 wR factor = 0.088 Data-to-parameter ratio = 12.5

For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.

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Alternative procedure for the synthesis
Alternative procedure for the synthesis of enantiopure 1-benzoyl-2(S)-tert-butyl-3-methylperhydropyrimidin-4-one, a useful starting material for the enantioselective synthesis of α-substituted β-amino acids
✍ Martı́n A. Iglesias-Arteaga; Elena Castellanos; Eusebio Juaristi 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 177 KB

The title heterocycle is prepared in enantiomerically pure form and in 46-50% overall yield from (S)-asparagine, a readily available starting material. The synthetic route described in this report represents a major improvement over the original procedure (Tetrahedron: Asymmetry 1991, 3, 723), that