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1-[(Benzofuran-2-yl) phenylmethyl] Imidazoles as Inhibitors of 17α-Hydroxylase: 17, 20-lyase (P450 17): Species and Tissue Differences

✍ Scribed by AMAR M. AL-HAMROUNI; MASOUD AHMADI; PAUL J. NICHOLLS; H. JOHN SMITH; PAULO LOMBARDI; V. PESTELLINI


Book ID
118110376
Publisher
Pharmaceutical Press
Year
1997
Tongue
English
Weight
407 KB
Volume
3
Category
Article
ISSN
2042-7158

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## Abstract The synthesis and biological evaluation of __Z__‐ and __E__‐1‐methyl‐2‐(1‐hydroximinoethyl)‐6‐methoxy‐3,4‐dihydro‐naphthalene (__Z__‐1 and __E__‐1) as nonsteroidal inhibitors of 17α‐hydroxylase‐C17,20‐lyase (P450 17, CYP17) is described. __Z__‐1 and __E__‐1 were separated by column chro