## Abstract For Abstract see ChemInform Abstract in Full Text.
1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors
✍ Scribed by Christopher D. Beadle; John Boot; Nicholas P. Camp; Nancy Dezutter; Jeremy Findlay; Lorna Hayhurst; John J. Masters; Roberta Penariol; Magnus W. Walter
- Book ID
- 108073744
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 155 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0960-894X
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## Abstract Two 2,3‐dihydro‐2‐(4‐pyridinyl)‐1__H__‐isoindoles 2a,b have been synthesized by the reaction of isoindoline with 4‐chloropyridines. In addition, a number of 1‐alkyl‐2,3‐dihydro‐2‐(4‐pyridinyl)‐1__H__‐isoindoles 2c‐h were obtained from 2‐(4‐pyridinyl)phthalimide (5). The addition of alky
a b s t r a c t Piperazinyl derivatives of 1-(arylsulfonyl)-2,3-dihydro-1H-quinolin-4-ones have been identified with high binding affinities for 5-HT 6 receptor. In particular, 2-methyl-5-(N-methyl-piperazin-1-yl)-1-(naphthalene-2-sulfonyl)-2,3-dihydro-1H-quinolin-4-one (8g) exhibits high binding af