✦ LIBER ✦

1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT6 serotonin receptor ligands

✍ Scribed by Chul Min Park; Jin Il Choi; Jung Hwan Choi; So Young Kim; Woo Kyu Park; Churl Min Seong

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 536 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.12.007

No coin nor oath required. For personal study only.

✦ Synopsis

a b s t r a c t Piperazinyl derivatives of 1-(arylsulfonyl)-2,3-dihydro-1H-quinolin-4-ones have been identified with high binding affinities for 5-HT 6 receptor. In particular, 2-methyl-5-(N-methyl-piperazin-1-yl)-1-(naphthalene-2-sulfonyl)-2,3-dihydro-1H-quinolin-4-one (8g) exhibits high binding affinity toward 5-HT 6 (IC 50 = 8 nM) receptor with good selectivity over other serotonin and dopamine receptors.

📜 SIMILAR VOLUMES

1,2,3,4-Tetrahydrocarbazoles as 5-HT6 Se

1,2,3,4-Tetrahydrocarbazoles as 5-HT6 Serotonin Receptor Ligands.

✍ Jean Chang-Fong; Jagadeesh B. Rangisetty; Malgorzata Dukat; Vincent Setola; Thom 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 89 KB 👁 1 views

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-ind

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as Novel 5-HT6 Receptor Ligands.

✍ Ronald Bernotas; Steven Lenicek; Schuyler Antane; Guo Ming Zhang; Deborah Smith; 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 13 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

ChemInform Abstract: [1,2,4]Triazole Der

ChemInform Abstract: [1,2,4]Triazole Derivatives as 5-HT1A Serotonin Receptor Ligands.

✍ Maria Concetta Sarva; Giuseppe Romeo; Francesco Guerrera; Mariangela Siracusa; L 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Synthesis of (R)-5-(Di[2,3-3H2]propylami

Synthesis of (R)-5-(Di[2,3-3H2]propylamino)5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one ([3H]U-86170) and (R)-5-([2,3-3H2]Propylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one ([3H]U-91356)

✍ Malcolm W. Moon; Richard S. P. Hsi 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 542 KB

## Abstract (__R__)‐5‐(diallylamino)‐5,6‐dihydro‐4__H__‐imidazo[4,5,1‐__ij__]quinolin‐2(1__H__)‐one (__12b__) was prepared in 9% overall yield from 3‐aminoquinoline. Reaction of __12b__ in ethyl acetate with tritium gas in presence of a 5% platinum on carbon catalyst afforded a mixture of (__R__)‐5

1,2,4-Benzothiadiazine Derivatives as α1

1,2,4-Benzothiadiazine Derivatives as α1 and 5-HT1A Receptor Ligands.

✍ Annalisa Tait; Amedeo Luppi; Silvia Franchini; Elisa Preziosi; Carlo Parenti; Mi 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 21 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

ChemInform Abstract: Quinolizidinyl Deri

ChemInform Abstract: Quinolizidinyl Derivatives of 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxylic Acid and 1-Homolupinanoyl Benzimidazolones as Ligands for 5-HT3 and 5-HT4 Receptors.

✍ Anna Sparatore; Alfredo Cagnotto; Fabio Sparatore 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views