Synthesis and SAR of 4-aryl-1-(indazol-5
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Mark Hadden; Dustin M. Deering; Alan J. Henderson; Matthew D. Surman; Michele Lu
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Article
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2010
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Elsevier Science
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English
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A new series of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones possessing MCH-1 receptor antagonism is presented. Suzuki coupling of boronic acids with key triflate 6 allowed rapid generation of a range of analogs. The SAR of the MCH-1 receptor was explored with a variety of aryl and heterocyclic moieties