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1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyano- pyrazi-2-yl)ureas as Potent and Selective Inhibitors of Chk1 Kinase: Synthesis, Preliminary SAR, and Biological Activities

✍ Scribed by Wang, Gary T.; Li, Gaoquan; Mantei, Robert A.; Chen, Zehan; Kovar, Peter; Gu, Wendy; Xiao, Zhan; Zhang, Haiying; Sham, Hing L.; Sowin, Thomas; Rosenberg, Saul H.; Lin, Nan-Horng


Book ID
120374504
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
269 KB
Volume
48
Category
Article
ISSN
0022-2623

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## Abstract magnified image A series of novel title compounds have been designed and synthesized by a multi‐step reaction, the stereochemistry of the reaction was investigated, the structures of all compounds prepared have been confirmed by ^1^H NMR, IR, EI‐MS spectroscopy and elemental analysis.