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1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one: A Selective High-Affinity Antagonist for the Human Dopamine D4 Receptor with Excellent Selectivity over Ion Channels

โœ Scribed by Carling, Robert W.; Moore, Kevin W.; Moyes, Christopher R.; Jones, Elizabeth A.; Bonner, Katrine; Emms, Frances; Marwood, Rosemary; Patel, Shil; Patel, Smita; Fletcher, Alan E.


Book ID
111967804
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
132 KB
Volume
42
Category
Article
ISSN
0022-2623

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A direct and specific comparison of a trifluoromethyl group with the corresponding pentafluorosulfanyl group is made in terms of primary affinity and pharmacokinetic properties.