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A specific and direct comparison of the trifluoromethyl and pentafluoro sulfanyl groups on the selective dopamine D3 antagonist 3-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-1-phenyl-3-azabicyclo[3.1.0]hexane template

✍ Scribed by Fabrizio Micheli; Daniele Andreotti; Simone Braggio; Anna Checchia

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
184 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

A direct and specific comparison of a trifluoromethyl group with the corresponding pentafluorosulfanyl group is made in terms of primary affinity and pharmacokinetic properties.

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