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(+)-1-{(2S)-2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl}-1H-imidazole mononitrate [(+)-(S)-miconazole nitrate]

✍ Scribed by Peeters, Oswald M. ;Blaton, Norbert M. ;Aeschlimann, Christine ;Gal, Joseph

Publisher: International Union of Crystallography
Year: 2004
Tongue: English
Weight: 205 KB
Volume: 60
Category: Article
ISSN: 1600-5368
DOI: 10.1107/s1600536804003058

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✦ Synopsis

The title compound, C 18 H 15 Cl 4 N 2 O + ÁNO 3 À , (+)-miconazole nitrate, is a component of racemic miconazole nitrate, a broad spectrum antimycotic agent with antibacterial activity. It crystallizes with two protonated molecules in the asymmetric unit, both with S con®guration, which are linked into a dimer by hydrogen bonds with the nitrate anions.

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(+)-1-{(2S)-2-(2,4-Di­chloro­phenyl)-2-[(2,4-di­chloro­phenyl)­methoxy]­ethyl}-1H-imidazole mononitrate [(+)-(S)-miconazole nitrate]

✦ Synopsis

(+)-1-{(2S)-2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl}-1H-imidazole mononitrate [(+)-(S)-miconazole nitrate]