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05 Methylation of MLH1, MGMT, DAPK genes in the cancerous and adjacent non-cancerous stomach tissues

✍ Scribed by R. Kupcinskaite-Noreikiene; E. Juozaityte; S. Grižas; R. Markelis; L. Venclauskas; V. Baltrėnas; L. Sakavicius; I. Semakina; R. Venclovaite; J. Skieceviciene


Book ID
117661886
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
48 KB
Volume
48
Category
Article
ISSN
0959-8049

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Methylation pattern of different regions
✍ Mirco Menigatti; Carmela Di Gregorio; Francesca Borghi; Elisa Sala; Alessandra S 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 2 views

## Abstract Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism of gene inactivation during tumorigenesis. We examined the methylation status of two distinct regions of the __MLH1__ promoter (proximal and distal to the transcription start site) and the __MLH1_