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043 IN VIVO EVIDENCE OF THE IMPLICATION OF PROTEINASE-ACTIVATED RECEPTOR (PAR)-2 IN CARTILAGE DEGRADATION IN A MOUSE MODEL OF OSTEOARTHRITIS

✍ Scribed by N. Amiable; J. Martel-Pelletier; J.-P. Pelletier; B. Lussier; F. Paré; S. Tremblay; C. Boileau


Book ID
114351255
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
110 KB
Volume
17
Category
Article
ISSN
1063-4584

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✍ Réjean Lebel; Beata Jastrzębska; Hélène Therriault; Marie-Michèle Cournoyer; J. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 918 KB

## Abstract A novel MRI proteinase‐modulated contrast agent (PCA) was developed to detect the activity of the proinvasive enzyme matrix metalloproteinase‐2 (MMP‐2) in vivo. The PCA2‐switch agent incorporates a solubility switch, where cleavage of a peptide substrate by MMP‐2 decreases the water sol