0043 Expression of a multidrug resistance gene product p170 glycoprotein in neoplastic breast tissues
โ Scribed by C. Gennatas; V. Michalaki; M. Frangou Plemenou; S. Gennatas; M. Tsantopoulos; A. Kondi-Pafiti
- Book ID
- 114316194
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 50 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0960-9776
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P-Glycoprotein (PGP), a product of the multidrug resistance gene (mdr), acts as an adenosine triphosphate-dependent drug efflux system in cells. Initially, PGP was found in cancer cells, but it is now known that PGP is richly distributed in the adult brain. Passage to the central nervous system is l
Multidrug resistance (MDR) in human cancer is often associated with over-expression of the mdr-1 gene, which encodes a 170-kDa transmembrane protein, termed P-glycoprotein (P-gp). We evaluated the immunoreactivity of P-gp in oral tissues at different stages of tumorigenesis in the Indian population
## BACKGROUND. It has been observed that patients who have previously undergone radiotherapy have a lower rate of response to chemotherapy. ## METHODS. The authors investigated the effects of radiation on the expression of P-glycoprotein (Pgp), a multidrug-resistance gene product, in 56 patient