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ω-iodophenyl fatty acids: A convenient method of radioiodination

✍ Scribed by C.A. Otto; H. Lee; T.J. Mangner; D.M. Wieland

Publisher
Elsevier Science
Year
1986
Weight
599 KB
Volume
37
Category
Article
ISSN
0883-2889

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✦ Synopsis

A solid-phase radioiodination technique for omega-iodophenyl fatty acids using ammonium sulfate is described. The radioiodinations are regioselective, high in yield (95%), short in reaction time (1 h) and capable of yielding high specific activity products although at lower yields. Purification is exceptionally simple: a single passage through an ion exchange column to remove unreacted I- is all that is required. Syntheses of several omega-iodophenyl fatty acids are also described.

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