✦ LIBER ✦

ω-Dialkylaminoalkyl ethers of phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with analgesic and anti-inflammatory activity

✍ Scribed by Giulia Menozzi; Luisa Mosti; Paola Fossa; Francesca Mattioli; Marco Ghia

Publisher: Journal of Heterocyclic Chemistry
Year: 1997
Tongue: English
Weight: 344 KB
Volume: 34
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570340339

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A series of carbinols 3a‐f was prepared starting from methanols 1a‐f via oxidation with pyridinium chlorochromate to aldehydes 2a‐f, followed by a Grignard reaction of the latter. Reaction of 3a‐f with ω‐chloroalkyldialkylamine hydrochlorides afforded a series of aminoether derivatives 4g‐t. Compounds 4i,m‐p,s showed a good analgesic activity in the acetic acid writhing test in mice. Moreover, compounds 4h,1,s exhibited a moderate anti‐inflammatory activity in the carrageenan‐induced edema assay in rats.

📜 SIMILAR VOLUMES

ChemInform Abstract: ω-Dialkylaminoalkyl

ChemInform Abstract: ω-Dialkylaminoalkyl Ethers of Phenyl-(5-substituted 1-phenyl-1H- pyrazol-4-yl)methanols with Analgesic and Antiinflammatory Activity.

✍ G. MENOZZI; L. MOSTI; P. FOSSA; F. MATTIOLI; M. GHIA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

ω-Dialkylaminoalkyl Ethers of Phenyl-(5-substituted 1-phenyl-1Hpyrazol-4-yl)methanols with Analgesic and Antiinflammatory Activity. -A new series of title amino ethers (VI) (12 examples) is synthesized from alcohols (I) and examined for their biological activities. Some derivatives display good ana

Synthesis and anti-inflammatory and anal

Synthesis and anti-inflammatory and analgesic activities of 3-methyl-N-phenyl-1 H-pyrazol-5-ylcarboxamides

✍ Gianni Vertuani; Paolo Giori; Mario Guarneri; Gian Pietro Sarto 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 305 KB

Synthesis, Characterization and Antimicr

Synthesis, Characterization and Antimicrobial Activities of Some Fluorine Containing 2-(1-Phenyl-3-aryl-1H-pyrazol-4-yl)-3-chlorochromones, 2-(1-Phenyl-3-aryl-1H-pyrazol-4-yl)chromones and 5-(1-Phenyl-3-aryl-1H-pyrazol-4-yl)-3- (2-hydroxyphenyl)-4,5-dihydropyrazolines.

✍ N. S. Joshi; A. A. Shaikh; A. P. Deshpande; B. K. Karale; S. B. Bhirud; C. H. Gi 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 21 KB 👁 2 views

ChemInform Abstract: 4-Dialkylamino-1-(5

ChemInform Abstract: 4-Dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1H-pyrazol-4-yl)butan-1-ols: Synthesis and Evaluation of Analgesic, Antiinflammatory, and Platelet Antiaggregating Activities.

✍ Giulia Menozzi; Luisa Mosti; Luisa Merello; Antonietta Piana; Ugo Armani; Marco 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

ChemInform Abstract: Synthesis and Antim

ChemInform Abstract: Synthesis and Antimicrobial Activity of 4-[5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl]dihydropyridines and 4-[5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl] -3,4-dihydropyrimidin-2-ones.

✍ Rakesh Kumar; Sakshi Malik; Ramesh Chandra 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Synthesis of Some N

ChemInform Abstract: Synthesis of Some Novel (1-Substituted-5-phenyl-3-trifluoromethyl-1H-pyrazol-4-yl)-(substituted benzothiazol-2-yl)-diazene and Their Antifungal Activity.

✍ V. Sareen; V. Khatri; D. Shinde; S. Sareen 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views