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ω-Aminoalkyl β-glycosides of N-acetylmuramyl-l-alanyl-d-isoglutamine, and their conjugates with meningococcal group C polysaccharide

✍ Scribed by Mitree M. Ponpipom; Kathleen M. Rupprecht


Book ID
107725321
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
454 KB
Volume
113
Category
Article
ISSN
0008-6215

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Methyl β-glycosides of N-acetyl-6-O-(ω-a
✍ Mitree M. Ponpipom; Kathleen M. Ruprecht 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 807 KB

Spacer arms 2.1-3.7 nm (21-37 A) long were prepared, and coupled with the methyl P-glycoside of ~-acetylmuramyl-L-alanyl-D-isoglutamine benzyl ester, to give blocked 6acylates. Deprotection was effected with palladium chloride and triethylsilane. Chemical conjugates of MDP-meningococcal group C poly