κ- and λ-positive cells in centroblastic-centrocytic lymphoma (follicular lymphoma) may share a secondary chromosome aberration: Reflections on early lymphoma development
✍ Scribed by Klaus Weber-Matthiesen; Martin Winkemann; Werner Grote; Brigitte Schlegelberger
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 495 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
The technique of simultaneous fluorescence immunophenotyping and interphase cytogenetics (FICTION) was applied in four cases of centroblastic-centrocytic (working formulation: follicular) lymphoma. Our aim in this study was to establish whether secondary chromosome aberrations known from a prior cytogenetic analysis were detectable in both K-and h-expressing tumor cells from the same lymphoma patient. One of the cases did indeed contain K-and A-positive tumor cells with trisomy 8. On the basis of our results, we reflect on the events that take place during early development of centroblastic-centrocytic lymphoma. Genes Chromosom Cancer /4:22-27 (/995). 0 I995 Wiley-Liss, Inc.