Δ9-tetrahydrocannabinol and its major metabolite Δ9-tetrahydrocannabinol-11-oic acid as 15-lipoxygenase inhibitors
✍ Scribed by Shuso Takeda; Rongrong Jiang; Hironori Aramaki; Masumi Imoto; Akihisa Toda; Reiko Eyanagi; Toshiaki Amamoto; Ikuo Yamamoto; Kazuhito Watanabe
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 257 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
15-Lipoxygenase (15-LOX)
is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein, a major causal factor for atherosclerosis. 9 -Tetrahydrocannabinol ( 9 -THC), a major component of marijuana, has suggested to suppress atherosclerosis. Although 9 -THC seems to be attractive for the prevention of atherosclerosis, there is no information about whether or not 15-LOX isoform can be inhibited by 9 -THC. In the present study, 9 -THC was found to be a direct inhibitor for 15-LOX with an IC 50 (50% inhibition concentration) value of 2.42 :M. Furthermore, 9 -THC-11-oic acid, a major and nonpsychoactive metabolite of 9 -THC, but not another 9 -THC metabolite 11-OH-9 -THC (psychoactive), was revealed to inhibit 15-LOX. Taken together, it is suggested that 9 -THC can abrogate atherosclerosis via direct inhibition of 15-LOX, and that 9 -THC-11-oic acid is shown to be an "active metabolite" of 9 -THC in this case.