γδ T-cell receptor-positive cells of human skin. II. Appearance in delayed-type hypersensitivity reaction

✍ Scribed by M. Fujita; Y. Miyachi; K. Nakata; S. Imamura

• Publisher: Springer-Verlag
• Year: 1993
• Tongue: English
• Weight: 878 KB
• Volume: 285
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00372140

✦ Synopsis

In order to investigate the distribution and involvement of human ~6 T-cell receptor-positive (TCR § cells in delayed-type hypersensitivity reactions of the skin, we examined the occurrence and kinetics of y6 TCR + cells during skin reactions of allergic contact dermatitis. In normal human skin sections, ~,J TCR + cells were scarce. In allergic contact dermatitis from DNCB, increased ~J TCR + cells were observed both in the epidermis and in the dermis from 48 h after the challenge. Most of the ~ TCR + cells were TCR~I + 6TCS1-BB3 + Ti~A + (V~l-V62 + vyg+). The percentage of y6 TCR + cells in the peripheral blood remained unchanged and a few ~6 TCR + cells in the skin lesions proliferated in situ. It is suggested that the y6 TCR + cells in skin lesions of allergic contact dermatitis may not be involved in initiation of delayed-type hypersensitivity but may have some other roles responding to factors induced in the reaction.