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γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes

✍ Scribed by Manuel Stucki; Stephen P. Jackson

Book ID: 116410546
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 284 KB
Volume: 5
Category: Article
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2006.01.012

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## Abstract After irradiation, ATM defective cells accumulate unrepaired double strand breaks (DSBs) for several cell divisions. At the chromosome level, unresolved DSBs appear as chromosome breaks that can be efficiently scored by using telomeric and mFISH probes. H2AX is immediately activated by