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Γ-HMBC: An NMR Experiment for the Conformational Analysis of the o-Glycosidic Linkage in Glycopeptides

✍ Scribed by Sergey Ilin; Carlos Bosques; Christopher Turner; Harald Schwalbe

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
127 KB
Volume
42
Category
Article
ISSN
0044-8249

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✦ Synopsis

Carbohydrates play a major role in many processes, such as the immunological response, and in cellular recognition events in general. [1] The structural characterization of carbohydrates by NMR spectroscopy has been a challenge because of the lack of experimental parameters and the intrinsic high mobility and resulting conformational averaging of oligosaccharides in solution. For example, the conformation around

[*] Prof.

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This communication describes the use of two-dimensional relayed (TOCSY)-ROESY experiments for the rapid and selective identification of alpha/beta1,2-glycosidic linkages in polysaccharides. The method assists in the identification of cross-peaks in crowded regions of ROESY spectra by moving them to