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βIV tubulin is selectively expressed by oligodendrocytes in the central nervous system

✍ Scribed by Nobuo Terada; Grahame J. Kidd; Mike Kinter; Carl Bjartmar; Kim Moran-Jones; Bruce D. Trapp

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
853 KB
Volume
50
Category
Article
ISSN
0894-1491

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✦ Synopsis

Oligodendrocyte differentiation and myelination involve dramatic changes in cell signaling pathways, gene expression patterns, cell shape, and cytoskeletal organization. In a pilot study investigating CNS angiogenesis, oligodendrocytes were intensely labeled by antisera directed against the C-terminal of Tie-2, a 140-kDa transmembrane receptor for angiopoietin. Immunoprecipitation of rat brain proteins with Tie-2 C-terminal antisera, however, produced a single spot of *55-kDa pI *5 by two-dimensional (2D) electrophoresis, which was identified as b-tubulin by mass spectrometry. Isotype-specific antibodies for b IV tubulin selectively labeled oligodendrocytes. First detected in premyelinating oligodendrocytes, b IV tubulin was abundant in myelinating oligodendrocyte perinuclear cytoplasm and processes extending to and along developing myelin internodes. b IV tubulin-positive MTs were diffusely distributed in oligodendrocyte perinuclear cytoplasm and not organized around the centrosome. b IV tubulin may play a role in establishing the oligodendrocyte MT network, which is essential for the transport of myelin proteins, lipids, and RNA during myelination. V

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